Table 7. Summary of study outcomes – Iron biomarkers vs. malaria risk, and outcomes not presented in forest plot.
Author, Year | Study Design | Biomarker(Outcome) | Exposure% (n or IQR) | Comparison to exposure% Outcome (n or IQR) | p-value |
Engmann 2008 [41] | Cross-sectional | Serum ferritin (μg/L) | Peripheral parasitemia at enrollment Median 91 (IQR: 33, 157) | No peripheral parasitemia at enrollment Median 33 (IQR: 20, 50) | Not provided |
Matteelli 1994 [42] | Cross-sectional | Serum ferritin (ng/mL) | Peripheral parasitemia at delivery Mean 65.7 (n = 106) | No peripheral parasitemia at delivery Mean 36.5 (n = 98) | p = 0.002 |
Ndyomugyenyi 2008 [61] | Cross-sectional | Serum ferritin (μg/L) | Peripheral parasitemia at enrollment (Means not available) | No peripheral parasitemia at enrollment (means not available) | p = 0.007 |
Saad 2012 [52] | Case-control | Serum ferritin (μg/L) | Peripheral parasitemia at enrollment (Uncomplicated malaria) Median 63.3 (IQR: 30.5, 113.2) | No peripheral parasitemia at enrollment Median 34.4 (IQR: 7.9, 60.3) | p = 0.041 |
Serum ferritin (μg/L) | Peripheral parasitemia at enrollment (Severe malaria) Median 78.6 (IQR: 44.1, 148.9) | No peripheral parasitemia at enrollment Median 34.4 (IQR: 7.9, 60.3) | p = 0.002 | ||
Dreyfuss 2000 [46] | Cross-sectional | Erythrocyte Protoporhyrin (μmol/mol heme) | Peripheral parasitemia at enrollment Geometric mean 90 (CI 54, 150) (n = 57) | No peripheral parasitemia at enrollment Geometric mean 84 (CI 52, 134) (n = 231) | P = 0.3 |
CI: confidence interval. IQR: Interquartal range.