Figure 4. Comparison of functional parameters of biliary epithelial cell function in DCD livers that were preserved by either 4 h of oxygenated HMP or 4 h of SCS and subsequently reperfused for 2 h by normothermic ex vivo sanguineous perfusion.

There were no significant differences in biliary pH (Panel A), biliary bicarbonate (Panel B) and glucose concentration (Panel C) at 2 h after reperfusion between the two groups. Relative mRNA expression of the main cholangiocyte transporter proteins involved in biliary bicarbonate secretion, CFTR (cystic fibrosis transmembrane conductance regulator; ABC35) (Panel D) and AE2 (anion exchanger 2; SLC4A2) (Panel E) after 2 h of ex vivo sanguineous reperfusion of DCD livers that were preserved by either 4 h of oxygenated HMP or SCS. There were no significant differences between the two groups.