Fig. 6. A proposed signaling network depicting the PDGF induced TRPC6 activation at the plasma membrane.

PDGF receptors dimerize upon binding to PDGF and cause the activation of receptor kinase activity. The activated PDGF receptors induce the activation of downstream Src, and PLC which generates IP₃ and DAG. IP₃ activates the IP₃ receptor at ER while DAG can activate TRPC6 at the plasma membrane, specifically on the lipid rafts to induce the Ca²⁺ influx across the plasma membrane. Intercellular tension generated by the actomyosin contractility can affect the interaction between actin cytoskeleton and membrane lipid raft/caveolae microdomains to regulate the structure and function of lipid rafts, which eventually determines the TRPC6 response to PDGF-induced signaling.