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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Nov 28;1843(2):366–371. doi: 10.1016/j.bbamcr.2013.11.016

Figure 2. The structural basis of the interactions of KMT2A PHD3 with H3K4me3 and Cyp33.

Figure 2

(a) The 1.9 Å-resolution crystal structure of the PHD3-BD region of KMT2A in complex with histone H3K4me3 peptide (PDB: 3LQJ). (b) The H3K4me3-binding site of the KMT2A PHD3 finger. (c) The solution structure of the Cyp33 RRM domain fused with the α1-helix of the KMT2A PHD3 finger (PDB: 2KU7).