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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Neurovirol. 2013 Aug 14;20(2):175–183. doi: 10.1007/s13365-013-0182-x

Figure 2. Dendritic cell infiltration into the CNS during SIV infection.

Figure 2

(A) After IHC-P staining, individual blood vessels in the frontal cortex were identified by CD31 staining (green) and macaque DC-SIGN staining (red) identified dendritic cells. The control group does not exhibit macDC-SIGN+ cells, however in SIV infection DCs are shown to transmigrate into the brain parenchyma. (B) Perivascular cuffing of dendritic cells is observed in SIV and SIV + morphine macaques at the site of SIV lesions as determined by staining with CD31 (green), macDC-SIGN (red) and SIV p27 (blue). Control animals do not show perivascular accumulation of lymphocytes. (C) Dendritic cells with a mature phenotype are observed in SIV and SIV + morphine animals, compared to control animals, as demonstrated by staining with HLA-DR (green) and CD83 (red) (red circle). Representative images at 40X magnification are shown.