Table 1.
Results of GWAS conducted in All-PD and stratified by Sporadic-PD and Familial-PD
| CHR Gene | SNP | Base pair position* | Minor/major allele |
Allele frequency |
Association with PD |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Case |
Control |
All-PD |
Sporadic-PD |
Familial-PD |
||||||||||||
| All-PD | Sporadic | Familial | OR | SE | P | OR | SE | P | OR | SE | P | |||||
|
Known highly significant loci | ||||||||||||||||
| 4 SNCA |
rs356220 |
90641340 |
T/C |
0.440 |
0.439 |
0.443 |
0.364 |
1.38 |
0.07 |
3×10-11 |
1.37 |
0.07 |
1×10-9 |
1.40 |
0.11 |
2×10-5 |
| 6 HLA |
rs3129882 |
32409530 |
G/A |
0.459 |
0.470 |
0.418 |
0.395 |
1.31 |
0.06 |
3×10-8 |
1.38 |
0.07 |
5×10-10 |
1.12 |
0.09 |
0.15 |
| 17 MAPT |
rs199498 |
44865603 |
C/T |
0.190 |
0.197 |
0.162 |
0.236 |
0.74 |
0.05 |
2×10-6 |
0.78 |
0.05 |
2×10-4 |
0.59 |
0.06 |
8×10-7 |
|
New Signals in NGRC | ||||||||||||||||
| 1 |
rs2338971 |
101880005 |
T/C |
0.187 |
0.179 |
0.213 |
0.232 |
0.74 |
0.04 |
2×10-7 |
0.71 |
0.04 |
4×10-8 |
0.86 |
0.08 |
0.12 |
| 8 |
rs12681349 |
4277990 |
T/C |
0.376 |
0.369 |
0.403 |
0.426 |
0.78 |
0.04 |
7×10-7 |
0.75 |
0.04 |
5×10-8 |
0.88 |
0.07 |
0.10 |
|
Replication | ||||||||||||||||
| 1 |
rs2338971 |
101880005 |
T/C |
0.184 |
0.182 |
0.188 |
0.212 |
0.82 |
0.06 |
5×10-3 |
0.81 |
0.07 |
6×10-3 |
0.83 |
0.08 |
0.03 |
| 8 |
rs12681349 |
4277990 |
T/C |
0.427 |
0.420 |
0.442 |
0.419 |
1.02 |
0.06 |
0.38 |
0.99 |
0.06 |
0.41 |
1.09 |
0.08 |
0.13 |
|
Pooled NGRC and Replication | ||||||||||||||||
| 1 | rs2338971 | 101880005 | T/C | 0.185 | 0.181 | 0.197 | 0.227 | 0.76 | 0.03 | 5×10-10 | 0.74 | 0.04 | 4×10-10 | 0.82 | 0.05 | 2×10-3 |
*Genome Build 37.