Table 1. Number of significant associations (in variants and genes) reported in candidate gene meta-analysis and pooled analysis and GWAS, by cancer site.
| MAa | GWASb | |||
|---|---|---|---|---|
| Cancer Site | Variantsc | Genesd | Variantsc | Genesd |
| Bladder | 15 | 14 | 10 | 10 |
| Blood-related (ALL, MCL, NHL) | 1 | 1 | — | — |
| Breast | 80 | 59 | 36 | 30 |
| Cervical | 4 | 4 | — | — |
| Colorectal | 30 | 23 | 17 | 14 |
| Endometrial | 2 | 1 | — | — |
| Esophageal | 9 | 9 | 4 | 4 |
| Gastric | 21 | 17 | 2 | 2 |
| Genitourinary | 2 | 2 | — | — |
| Glioma | 18 | 13 | 9 | 8 |
| Head and neck | 14 | 11 | — | — |
| Hepatocellular | 8 | 4 | 4 | 6 |
| Hodgkin lymphoma | — | — | 4 | 3 |
| Laryngeal | 2 | 2 | — | — |
| Leukemia | 4 | 4 | 32 | 27 |
| Lung | 32 | 23 | 25 | 22 |
| Meningioma | 1 | 1 | — | — |
| Myeloproliferative | — | — | 1 | 1 |
| Nasopharyngeal | 4 | 3 | 6 | 6 |
| Neuroblastoma | — | — | 5 | 3 |
| Non-Hodgkin lymphoma | 10 | 8 | 2 | 2 |
| Oral | 1 | 1 | — | — |
| Ovarian | 14 | 12 | 10 | 10 |
| Pancreatic | — | — | 21 | 21 |
| Prostate | 53 | 40 | 56 | 35 |
| Renal cell | — | — | 3 | 3 |
| Skin | 20 | 8 | 8 | 7 |
| Testicular | — | — | 12 | 10 |
| Thyroid | — | — | 2 | 2 |
| Upper aero-digestive tract | 2 | 2 | — | — |
| Upper aero-digestive tract and lung | 1 | 1 | — | — |
| Urothelial | 1 | 1 | — | — |
| Total | 349 | 264 | 269 | 223 |
Abbreviations: ALL, adult lymphoblastic leukemia; GWAS, genome-wide association studies; MA, meta-analyses or pooled analyses; MCL, myeloid cell leukemia; NHL, non-Hodgkin lymphoma.
Total significant associations reported in previous systematic review of meta-analyses (Dong et al8) and meta-analyses and pooled data of individual studies published from 20 March 2008 through 26 February 2011. Meta-analyses were defined as those of candidate gene studies. Significance threshold was 0.05.
From GWAS catalog. Excludes variants that were not reported. GWAS with meta-analyses included were considered GWAS. Significance threshold was 1 × 10−5.
Some variants may be linked to one another due to proximity. Associations with combinations of two or more variants were considered unique, even if listed standalone variants were also reported.
Intergenic regions used if no gene provided by paper or associated with variant.