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. 2013 Jul 24;22(3):402–408. doi: 10.1038/ejhg.2013.161

Table 3. Noteworthy associations only found in meta- and pooled analyses of candidate gene studies.

Locus Source/PMIDa Gene/region Variant OR 95% CI lower 95% CI upper P-valueb FPRP at prior probability of 0.001 and OR 1.5 FPRP at prior probability of 0.000001 and OR 1.5 FPRP at prior probability of 0.001 and OR 1.2 FPRP at prior probability of 0.000001 and OR 1.2
Blood-related cancer
 11q13.3 18843022 CCND1 rs17852153 1.62 1.28 2.05 0.0001 0.184 0.996 0.904 1.000
                       
Breast cancer
 2q13 20437198 IL1B rs1143627 1.4 1.17 1.67 1.8E-04 0.191 0.996 0.809 1.000
 2q33.1 Dong CASP8 rs1045485 0.89 0.85 0.94 5.7E-06 0.028 0.967 0.029 0.967
  19629679     0.874 0.834 0.917 3.9E-08 <0.001 0.037 <0.001 0.038
 2q33.2 20920330 CTLA4 rs231775 1.31 1.17 1.48 1.4E-05 0.014 0.936 0.153 0.995
 5p12 21194473 MRPS30 rs10941679 1.12 1.09 1.15 <1.e-30 <0.001 <0.001 <0.001 <0.001
 17q22 21194473 COX11/STXBP4 rs6504950 0.95 0.92 0.97 1.4E-06 0.001 0.583 0.001 0.583
 19q13.2 Dong TGFB1 rs1800470 1.16 1.08 1.25 6.9E-05 0.090 0.990 0.108 0.992
 20q13.2 19823929 AURKA rs2273535 1.23 1.1 1.37 1.7E-04 0.143 0.994 0.338 0.998
 22q12.1 Dong CHEK2 1100delC 2.4 1.8 3.2 2.5E-09 0.004 0.782 0.678 1.000
                       
Colorectal cancer
 1p26.22 19846566 MTHFR rs1801133 0.83 0.77 0.9 6.5E-06 0.006 0.866 0.014 0.933
 11q22.2 19843588 MMP1 rs1799750 1.48 1.26 1.74 2.1E-06 0.004 0.785 0.270 0.997
 12q15 20503107 MDM2 rs2279744 0.73 0.62 0.86 1.7E-04 0.163 0.995 0.747 1.000
 19q13.2 20012233 TGFB1 rs1800469 1.62 1.3 2.02 1.8E-05 0.069 0.987 0.826 1.000
 22q11.23 Dong GSTT1 GSTT1 null 1.37 1.17 1.6 8.1E-05 0.074 0.988 0.598 0.999
                       
Endometrial cancer
 15q21.2 19124504 CYP19A1 rs749292 1.3 1.17 1.45 2.5E-06 0.002 0.714 0.032 0.971
                       
Esophageal cancer
 1q31.1 21304218 PTGS2 rs20417 1.45 1.23 1.71 1.0E-05 0.015 0.939 0.451 0.999
 4q23 20806441 ADH1B rs1229984 1.32 1.17 1.49 7.1E-06 0.007 0.878 0.103 0.991
 16q12.2 20360147 MMP2 rs243865 0.7 0.59 0.82 9.9E-06 0.013 0.932 0.392 0.998
 17p13.1 20827430 TP53 rs1042522 1.43 1.23 1.68 1.4E-05 0.018 0.950 0.451 0.999
                       
Gastric cancer
 1p36.22 Dong MTHFR rs1801133 1.52 1.31 1.77 4.9E-08 <0.001 0.140 0.057 0.984
 2q13 20360147 MMP7 rs11568818 1.79 1.37 2.34 2.1E-05 0.173 0.995 0.923 1.000
 4q13.3 19777350 IL-8 rs4073 1.363 1.199 1.527 9.2E-08 <0.001 0.088 0.007 0.868
 19q13.32 20981556 ERCC2 rs13181 0.3 0.21 0.44 7.2E-10 0.032 0.971 0.894 1.000
                       
Head and neck cancers
 11q22.2 19843588 MMP1 rs1799750 1.43 1.2 1.69 2.7E-05 0.037 0.974 0.577 0.999
                       
Hepatocellular carcinoma
 12q15 21240526 MDM2 rs2279744 1.57 1.36 1.8 1.0E-10 <0.001 <0.001 0.002 0.632
                       
Leukemia
 1p13.3 Dong GSTM1 GSTM1 null 1.2 1.14 1.25 8.6E-15 <0.001 <0.001 <0.001 <0.001
 22q11.23 Dong GSTT1 GSTT1 null 1.19 1.14 1.29 3.5E-08 0.023 0.960 0.039 0.976
                       
Lung cancer
 1p13.3 and  22q11.23 19124497 GSTM1, GSTT1 GSTM1 and GSTT1 present 0.71 0.62 0.82 3.2E-06 0.004 0.797 0.177 0.995
 10q26.3 20031389 CYP2E1 rs2031920 0.8 0.72 0.89 4.1E-05 0.039 0.976 0.153 0.994
 12q15 Dong MDM2 rs2279744 1.27 1.12 1.44 2.E-04 0.162 0.995 0.505 0.999
 16q12.2 20360147 MMP2 rs2285053 0.72 0.61 0.85 1.0E-04 0.113 0.992 0.713 1.000
      rs243865 0.55 0.48 0.63 6.2E-18 <0.001 <0.001 <0.001 <0.001
 19q13.31 Dong XRCC1 rs25487 1.34 1.16 1.54 5.E-05 0.038 0.975 0.383 0.998
  19116388   rs3213245 1.46 1.25 1.7 1.E-06 0.002 0.633 0.159 0.995
 19q13.32 Dong ERCC2 rs13181 1.3 1.13 1.49 2.E-04 0.143 0.994 0.566 0.999
                       
Nasopharyngeal cancer
 1p13.3 19338664 GSTM1 GSTM1 null 1.42 1.21 1.66 1.1E-05 0.014 0.935 0.383 0.998
                       
Non-Hodgkin lymphoma
 4p14 19029192 TLR rs4833103 0.75 0.64 0.87 2.E-04 0.134 0.994 0.639 0.999
                       
Prostate cancer
 1q25.3 Dong RNASEL rs627928 1.27 1.13 1.44 1.E-03 0.162 0.995 0.505 0.999
 8p21.2 20564319 NKX3-1 rs1512268 1.17 1.12 1.23 2.E-12 <0.001 <0.001 <0.001 <0.001
 17q24.3 20564319 LOC124685 rs1859962 1.21 1.12 1.3 8.E-07 <0.001 0.161 <0.001 0.318
 19q13.2 20564319 LOC644330 rs887391 1.14 1.08 1.2 7.E-07 <0.001 0.356 <0.001 0.362

Abbreviations: CI, confidence intervals; FPRP, false-positive report probabilities; OR, odd ratios.

FPRPs in bold indicate values that are ≤0.2 and are therefore considered noteworthy.

Table does not include associations for which FPRPs could not be calculated due to missing ORs and CIs.

a

‘Dong' indicates variants reported in previous systematic review of meta-analyses (Dong et al8).

b

Italicized P-values indicate those derived from calculation using methods described in Wacholder et al.12 All other values are as reported in source noted.