Fig. 5.

TUDCA pretreatment prevented ER stress induces during liver regeneratin in simple fatty liver. a The mRNA levels of GRP78, sXBP-1, and CHOP at 24 h after PHx with or without TUDCA pretreatment measured by real-time RT-PCR. b The expression of GRP78 protein at 24 h after PHx with or without TUDCA pretreatment detected by Western blotting and immunohistochemical staining (original magnification ×100). c The expression of sXBP-1 protein at 24 h after PHx with or without TUDCA pretreatment detected by Western blotting and immunohistochemical staining (original magnification ×200) (black squares Control, dark gray squares Control with TUDCA, white squares HFD, light gray squares HFD with TUDCA, n = 4–6; mean ± SE, *p < 0.05 mice with TUDCA pretreatment vs. mice without TUDCA pretreatment fed the same diet at each time point by ANOVA and Wilcoxon test)