Table 5.

We calculated univariate confidence intervals for parameter estimates by allowing 10 % deterioration of fitness value

Parameter	Interval	In percent
EXP(log10(tumour volume T diag))	[T diag−0.028;T diag+0.023]	[−0.3 %;+0.2 %]
EXP(immunogenicity ρ)	[ρ−5⋅10−4;ρ+6⋅10−4]	[−0.6 %;+0.8 %]
EXP(tumour growth α)	[α−9⋅10−4;α+7⋅10−4]	[−0.8 %;+0.7 %]
EXP(chemosensitivity k T)	[k T−0.022;k T+0.025]	[−0.9 %;+1.1 %]
effector toxicity k E	[k E−2⋅10−4;k E+0.013]	[−0.05 %;+2.7 %]
CHOEP exponent eff. tox e E	[e E−0.141;e E+0.114]	[−5.8 %;+4.7 %]
SD(immunogenicity ρ)	[sd(ρ)−0.003;sd(ρ)+0.003]	[−6.9 %;+7.1 %]
SD(log10(tumour volume) T diag)	[sd(T diag)−0.041;sd(T diag)+0.030]	[−8.8 %;+6.2 %]
CHOEP exponent chemosens e T	[e T−0.061;e T+0.078]	[−7.6 %;+9.8 %]
SD(chemosensitivity k T)	[sd(k T)−0.069;sd(k T)+0.048]	[−22.5 %;+15.6 %]
prop. hazard factor lhr	[lhr−0.048;lhr+0.040]	[−29.1 %;+24.1 %]