Table 2.

mRNA Fold Changes of Mitochondrial, Synaptic and Alzheimer’s Disease-Related Genes in 2-month-old VDAC +/− Mice Relative to VDAC +/+ Mice.

Genes		mRNA Fold Changes	P Values
AD-related Genes	APP	−1.3*	0.01
	Tau	−1.4*	0.03
	BACE 1	−1.2	0.3
	Presenilin 1	−1.2	0.2
	Presenilin 2	−1.4*	0.04
	GSK-3α	−1.2	0.2
	GSK-3β	−1.3*	0.04
Synaptic Genes	Synaptophysin	1.5*	0.01
	PSD-95	1.3	0.4
	Synapsin 1	1.6*	0.01
	Synapsin 2	1.8*	0.03
	Synaptobrevin 1	1.3*	0.04
	Synaptobrevin 2	1.3*	0.02
	Neurogranin	1.7**	0.003
	GAP43	1	0.7
	Synaptopodin	1.2	0.18
Mitochondrial Dynamics Genes	DRP1	−1.2	0.14
	FIS1	−1.2	0.35
	Mfn1	1.5*	0.04
	Mfn2	1.2	0.07
	OPA1	1.2	0.71
	Cyclophylin D	−1.4*	0.01
	VDAC	−1.7*	0.02
	ANT	−1.6*	0.03
	BCL-XL	1.0	0.83
	Hexokinase 1	1.4*	0.01
	Hexokinase 2	1.4*	0.02
Mitochondrial-encoded Electron Transport Chain Genes	ND3-Complex I	1.0	0.95
	ND6-Complex I	1.1	0.3
	CytB-Complex III	−1.2	0.09
	COX1-Complex IV	−1.3*	0.02
	COX2-Complex IV	−1.2	0.06
	ATP6-Complex V	1.2	0.14