Table 1.
SVM based highest prediction performances (on the basis of MCC) of different composition approaches for the discrimination between non-coding and coding RNAs
|
Approach |
Main dataset |
Independent dataset |
CONC dataset |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SN | SP | ACC | MCC | SN | SP | ACC | MCC | SN | SP | ACC | MCC | |
|
MNC |
56.67 |
87.13 |
75.08 |
0.47 |
63.95 |
81.15 |
74.34 |
0.46 |
50.19 |
90.48 |
77.48 |
0.46 |
|
DNC |
97.13 |
94.27 |
95.40 |
0.91 |
95.93 |
95.08 |
95.42 |
0.91 |
81.54 |
91.15 |
88.04 |
0.73 |
|
TNC |
98.90 |
99.04 |
98.98 |
0.98 |
98.65 |
98.79 |
98.74 |
0.97 |
86.33 |
95.39 |
92.47 |
0.83 |
|
TTNC |
99.50 |
99.35 |
99.41 |
0.99 |
99.29 |
99.05 |
99.15 |
0.98 |
89.51 |
94.98 |
93.22 |
0.85 |
|
PNC |
98.62 |
98.55 |
98.58 |
0.97 |
98.78 |
98.29 |
98.49 |
0.97 |
88.43 |
95.64 |
93.31 |
0.85 |
| Hybrid | 99.46 | 99.46 | 99.46 | 0.99 | 99.11 | 99.18 | 99.15 | 0.98 | 89.10 | 96.29 | 93.97 | 0.86 |
The MNC, DNA, TNC, TTNC and PNC approaches are mono-, di-, tri-, tetra- and penta-nucleotide compositions respectively. Hybrid is a combined approach based prediction of all predicated SVM scores of MNC, DNC, TNC, TTNC and PNC approaches.