Table 2.
Overall performance of HRP-2 test in asymptomatic carriers across three screening campaigns
| Campaign 1 | Campaign 2 | Campaign 3 | |
|---|---|---|---|
|
Sensitivity, % (95% CI) |
92.4 (91.4, 93.5) |
84.0 (79.3, 88.6) |
77.8 (71.5, 84.0) |
|
Specificity, % (95% CI) |
74.6 (73.1, 76.1) |
87.9 (87.0, 88.7) |
95.9 (95.4, 96.4) |
|
Positive predictive value, % (95% CI) |
73.8 (72.2, 75.3) |
23.2 (20.3, 26.0) |
35.4 (30.5, 40.2) |
|
Negative predictive value, % (95% CI) |
92.7 (91.7, 93.7) |
99.2 (99.0, 99.5) |
99.3 (99.1, 99.5) |
|
False-positive rate |
0.25 |
0.12 |
0.04 |
|
False-negative rate |
0.08 |
0.16 |
0.22 |
|
Positive likelihood ratio |
3.64 |
6.92 |
19.01 |
|
Negative likelihood ratio |
0.10 |
0.18 |
0.23 |
|
Accuracy |
0.82 |
0.88 |
0.95 |
| Kappa, % (95% CI) | 65.2 (63.2, 67.1) | 31.9 (28.3, 35.4) | 46.6 (41.4, 51.8) |