Table 3.
Performance of HRP-2 test in asymptomatic carriers by age and parasite density
| Age group (years) | Parasite density (/μl) | N | Positive | Negative | Sensitivity % (95% CI) | Specificity % (95% CI) |
|---|---|---|---|---|---|---|
|
0- <5 |
0-99 |
2,663 |
433 |
2,230 |
74.6 (64.5, 84.8) |
|
| |
100-499 |
90 |
83 |
7 |
92.2 (86.7, 97.8) |
|
| |
500-999 |
86 |
85 |
1 |
98.8 (96.6, 100) |
|
| |
1,000-4,999 |
211 |
209 |
2 |
99.1 (97.7, 100) |
|
| |
≥5,000 |
117 |
114 |
3 |
97.4 (94.6, 100) |
|
| |
Overall |
3,167 |
924 |
2,243 |
94.6 (92.8, 96.5) |
85.3 (84.0, 86.7) |
|
5-9 |
0-99 |
2,147 |
327 |
1,820 |
84.0 (75.7, 92.3) |
|
| |
100-499 |
184 |
171 |
13 |
92.9 (89.2, 96.6) |
|
| |
500-999 |
145 |
143 |
2 |
98.6 (96.7, 100) |
|
| |
1,000-4,999 |
246 |
245 |
1 |
99.6 (98.8, 100) |
|
| |
≥5,000 |
69 |
68 |
1 |
98.6 (95.7, 100) |
|
| |
Overall |
2,791 |
954 |
1,837 |
96.0 (94.5, 97.4) |
87.3 (85.8, 88.7) |
|
10-14 |
0-99 |
2,124 |
346 |
1,778 |
85.5 (79.8, 91.2) |
|
| |
100-499 |
215 |
206 |
9 |
95.8 (93.1, 98.5) |
|
| |
500-999 |
104 |
103 |
1 |
99.0 (97.2, 100) |
|
| |
1,000-4,999 |
145 |
144 |
1 |
99.3 (98.0, 100) |
|
| |
≥5,000 |
31 |
31 |
|
100 (100, 100) |
|
| |
Overall |
2,619 |
830 |
1,789 |
95.0 (93.3, 96.7) |
88.8 (87.4, 90.2) |
|
≥15 |
0-99 |
8,287 |
1,129 |
7,158 |
73.1 (68.8, 77.5) |
|
| |
100-499 |
310 |
265 |
45 |
85.5 (81.6, 89.4) |
|
| |
500-999 |
107 |
101 |
6 |
94.4 (90.0, 98.8) |
|
| |
1,000-4,999 |
66 |
64 |
2 |
97.0 (92.8, 100) |
|
| |
≥5,000 |
17 |
10 |
7 |
58.8 (35.4, 82.2) |
|
| Overall | 8,787 | 1,569 | 7,218 | 81.4 (78.8, 83.9) | 89.4 (88.7, 90.1) |
N = number of subjects for whom RDT and microscopy results were available.