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. Author manuscript; available in PMC: 2014 Feb 15.
Published in final edited form as: Am J Med. 2012 Apr;125(4):327–336. doi: 10.1016/j.amjmed.2011.09.010

Table 3.

Clinical, Immunological and Genetic Variables That May Influence B-cell Depletion in Patients with SLE Treated with Rituximab39–44

Variables Effect on B-cell Depletion
Afro-Caribbean origin Early repopulation (<6 months)
Anti-Sm+ carriers Early repopulation (<6 months)
Low IgA levels at baseline Depletion >6 months
Low IgG levels at baseline Depletion >6 months
Serum rituximab levels Correlation with % of peripheral B cells at 2 months
FcγrIIIa genotype Independent predictor of B-cell depletion
High numbers of CD19+ B lymphocytes at baseline Shorter depletion time

IgA = immunoglobulin A; IgG = immunoglobulin G; SLE = systemic lupus erythematosus.