Fig. 2.

Apolipoprotein CIII incubation increases whole-cell Ca²⁺ currents and coincubation with the Ca_V1 channel blocker nimodipine abrogates the effect of apolipoprotein CIII incubation in RINm5F cells. a Sample whole-cell Ca²⁺ current traces from a cell incubated with vehicle solution as control (cell capacitance: 10.1 pF) and apolipoprotein CIII (ApoCIII)-treated cell (cell capacitance: 11.1 pF). b Average Ca²⁺ current density–voltage relationships in control cells (open circles, n = 26) and cells treated with ApoCIII (filled circles, n = 26). *p < 0.05 versus control. c Sample whole-cell Ca²⁺ current traces from a nimodipine (Nim)-incubated cell (cell capacitance: 10 pF) and a cell exposed to Nim together with ApoCIII (Nim/ApoCIII) (cell capacitance: 11.9 pF). d Average Ca²⁺ current density–voltage relationships in Nim-treated cells (open circles, n = 20) and cells incubated with Nim/ApoCIII (filled circles, n = 21)