Table 4.
Univariable analysis of breast cancer mortality in invasive lobular carcinoma
| Prognostic factor | n | # events | HR | 95% CI | p-value |
|---|---|---|---|---|---|
| Age (years) | 192 | 60 | 0.97 | 0.95-0.99 | 0.01 |
| Tumour size (mm) | |||||
| ≤20 | 108 | 24 | 1.0 | ||
| >20 | 81 | 36 | 2.7 | 1.6-4.5 | <0.001 |
| Nodal status (p <0.001)a | |||||
| 0 | 107 | 27 | 1.0 | ||
| 1-3+ | 36 | 10 | 1.1 | 0.55-2.4 | 0.73 |
| >3+ | 38 | 21 | 3.5 | 2.0-6.2 | <0.001 |
| Histological grade (p =0.01)a | |||||
| 1 | 28 | 5 | 0.54 | 0.21-1.4 | 0.19 |
| 2 | 133 | 43 | 1.0 | ||
| 3 | 14 | 6 | 2.8 | 1.2-6.7 | 0.02 |
| Tubule formation | |||||
| 2 | 13 | 3 | 1.0 | ||
| 3 | 162 | 51 | 1.3 | 0.39-4.0 | 0.70 |
| Pleomorphism (p =0.04)a | |||||
| 1 | 20 | 5 | 0.88 | 0.34-2.3 | 0.80 |
| 2 | 112 | 31 | 1.0 | ||
| 3 | 43 | 18 | 1.9 | 1.0-3.3 | 0.03 |
| Mitotic score (p <0.001)a | |||||
| 1 | 155 | 45 | 1.0 | ||
| 2 | 10 | 4 | 2.0 | 0.71-5.6 | 0.19 |
| 3 | 10 | 5 | 4.2 | 1.7-11 | 0.003 |
| ER | |||||
| + | 169 | 50 | 1.0 | ||
| - | 23 | 10 | 1.6 | 0.83-3.3 | 0.15 |
| PgR | |||||
| + | 97 | 27 | 1.0 | ||
| - | 95 | 33 | 1.4 | 0.85-2.4 | 0.18 |
| Ki67 (p = 0.01)a | |||||
| 0-10% | 115 | 30 | 1.0 | ||
| 11-30% | 62 | 22 | 1.4 | 0.84-2.5 | 0.19 |
| >30% | 15 | 8 | 2.6 | 1.2-5.8 | 0.01 |
| KiGE | |||||
| Low | 136 | 35 | 1.0 | ||
| High | 39 | 19 | 2.8 | 1.6-5.0 | <0.001 |
aLog-rank test for trend.