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. Author manuscript; available in PMC: 2014 Feb 16.
Published in final edited form as: Ann N Y Acad Sci. 2011 Dec;1246:1–10. doi: 10.1111/j.1749-6632.2011.06347.x

Figure 3.

Figure 3

Specific defective peripheral B cell tolerance checkpoint in CD40L- and MHC class II-deficient patients. The frequencies of HEp-2 reactive (A), polyreactive (B), and antinuclear (C) mature naive B cells are compared between controls (open diamonds), subjects with the PTPN22 “T” risk allele, patients with diverse PID, rheumatoid arthritis (RA), and type 1 diabetes (T1D) (black diamonds). Defects in CD40L expression or antigen presentation through MHC class II molecules specifically either interfere with the removal or fail to prevent the accumulation of autoreactive B cells in the periphery. All other subjects who presented central B cell tolerance defects also display large numbers of autoreactive B cells in their mature naive B cell compartment.