TABLE 2.

Univariate Survival Analysis for the Entire Patient Cohort (n = 149) by Respective Clinical or Pathologic Variable

Variable	Overall Survival, P	Disease-Free Survival, P	Disease-Specific Survival, P
Sex†	0.98	0.79	0.34
Race (White vs. other)	0.74	0.83	0.28
Smoking (ever vs. never)	0.006	0.021	0.29
Treatment (surgery alone vs. postoperative radiation)	0.75	0.66	0.42
Chemotherapy (yes or no)	0.75	0.52	0.50
T-stage (%)	< 0.001	< 0.001	< 0.001
T1-T2
T3-T4
N-stage (%)	0.21	0.89	0.06
N0 vs. N1-N3
Extracapsular extension	0.047	0.018	0.075
None vs. present
Extracapsular extension	0.004	< 0.001	0.019
None or limited vs. extensive
Resection margin status	0.93	0.71	0.97
p16 immunohistochemistry*	< 0.001	< 0.001	0.094
Histologic type	< 0.001	< 0.001	0.67
Tumor cell anaplasia	< 0.001	0.006	0.002
Tumor cell multinucleation	0.001	0.002	0.005
Tumor cell anaplasia or multinucleation	0.003	0.007	0.005

^*Defined as positive if >50% of tumor cells stained and negative if no staining or < 50% of tumor cells stained.

^†P-values calculated from log-rank tests.

Values in bold are statistically significant (P < 0.05).