TABLE 3.

Multivariate Cox Model Analysis for the Entire Patient Cohort (n = 149) Including Tumor Cell Anaplasia and the Major Clinical or Pathologic Variables

	P HR (95% CI)
Variable	Overall Survival	Disease-Free Survival	Disease-Specific Survival
Smoking (ever vs. never)	0.067	0.17	0.38
	2.8 (0.93-8.94)	2.0 (0.75-5.15)	2.7 (0.29-24.06)
T-stage (T1/T2 vs. T3/T4)	0.011	0.011	0.009
	2.9 (1.27-6.40)	2.6 (1.25-5.55)	8.6 (1.70-43.19)
Histologic type 1 vs. type 2	0.90	0.57	0.18
	0.8 (0.13-4.35)	0.6 (0.12-3.17)	8.3 (0.37-185.17)
Histologic type 1 vs. type 3	0.91	0.96	0.28
	0.9 (0.15-5.54)	1.0 (0.18-5.18)	5.9 (0.24-141.68)
p16 IHC* (positive vs. negative)	0.42	0.31	0.39
	0.49 (0.09-2.82)	0.43 (0.08-2.17)	0.30 (0.02-4.68)
Anaplasia (positive vs. negative)	0.13	0.26	0.036
	1.9 (0.83-4.45)	1.6 (0.72-3.43)	9.9 (1.16-83.80)

^*Defined as positive if >50% of tumor cells stained and negative if no staining or < 50% of tumor cells stained.

CI indicates confidence interval; IHC, immunoliistocliemistry.

Values in bold are statistically significant (P < 0.05).