Table 3.
PLIN haplotypes and the risk of type 2 diabetes according to central obesity
| Polymorphisms | Frequency | Odds Ratios | P | Global, P | ||||
|---|---|---|---|---|---|---|---|---|
| rs2289487 | rs8179043 | rs894160 | Cases | Controls | (95% CI) | |||
| Non-obese | ||||||||
| H1 | 1 | 1 | 1 | 55.9 | 62.5 | 1.0 | - | 0.01 |
| H2 | 2 | 2 | 2 | 32.7 | 28.5 | 1.44, 1.09–1.91 | 0.01 | |
| H3 | 2 | 1 | 1 | 9.4 | 7.3 | 1.70, 1.04–2.77 | 0.03 | |
| Obese | ||||||||
| H1 | 1 | 1 | 1 | 66.2 | 60.9 | 1.0 | - | 0.32 |
| H2 | 2 | 2 | 2 | 27.2 | 30.0 | 0.86, 0.62–1.19 | 0.37 | |
| H3 | 2 | 1 | 1 | 5.2 | 7.1 | 0.66, 0.36–1.21 | 0.18 | |
H1-H3, haplotype 1-haplotype 3. ‘1’ codes the common and ‘2’ codes the minor alleles; analyses were adjusted for age, body mass index, alcohol consumption, physical activity, family history of diabetes, and menopausal status.