Table 3.
Regressions of language performance with grey matter atrophy and reduced white matter fractional anisotropy
| MNI coordinates
|
|||||
|---|---|---|---|---|---|
| Anatomic locus (Brodmann area) | x | y | z | Z score | Cluster size (voxels) |
| Grey matter atrophy regressions | |||||
| naPPA cleft | |||||
| L anterior-superior temporal (21) | −64 | −6 | −16 | 3.37 | 98 |
| naPPA centre-embedded | |||||
| L anterior-superior temporal (38) | −56 | 14 | −18 | 2.96* | 182 |
| lvPPA centre-embedded | |||||
| L posterior-superior temporal (42) | −50 | −28 | 16 | 3.18 | 57 |
| L inferior parietal (39) | −44 | −54 | 28 | 3.11 | 12 |
| svPPA centre-embedded | |||||
| L middle temporal (21) | −66 | −38 | −16 | 3.00* | 37 |
| bvFTD long | |||||
| L prefrontal (9) | −34 | 22 | 28 | 3.09* | 204 |
| L anterior cingulate (24) | −4 | 4 | 38 | 2.98* | 110 |
| L superior temporal (22) | −54 | −34 | 4 | 3.72 | 58 |
| R prefrontal (46) | 44 | 26 | 22 | 3.75 | 229 |
| R inferior frontal (6) | 36 | 4 | 34 | 3.21 | 170 |
| R superior temporal (22) | 54 | −42 | 10 | 3.62 | 48 |
| R middle temporal (21) | 50 | −38 | 4 | 3.24 | 124 |
| R postcentral (2) | 44 | −26 | 38 | 4.32 | 42 |
| bvFTD centre-embedded | |||||
| L prefrontal (9) | −34 | 22 | 28 | 3.44 | 232 |
| L prefrontal (46) | −28 | 46 | 18 | 3.07* | 37 |
| L superior temporal (22) | −54 | −36 | 2 | 3.47 | 58 |
| R inferior frontal (6) | 50 | 2 | 28 | 3.64 | 213 |
| R prefrontal (46) | 44 | 26 | 22 | 3.64 | 242 |
| R superior temporal (22) | 54 | −42 | 10 | 3.26 | 47 |
| R middle temporal (21) | 50 | −40 | 4 | 3.48 | 144 |
| R postcentral (2) | 44 | −26 | 38 | 4.51 | 39 |
| Reduced white matter fractional anisotropy regressions | |||||
| naPPA cleft | |||||
| L corpus callosum (body-anterior)/corona radiata | −17 | 8 | 30 | 4.14 | 187 |
| naPPA centre-embedded | |||||
| L inferior frontal-occipital | −33 | −43 | 16 | 3.75 | 90 |
| lvPPA centre-embedded | |||||
| L inferior frontal-occipital | −24 | 19 | 0 | 4.36 | 66 |
| L inferior longitudinal | −36 | −56 | −2 | 3.54 | 195 |
| R corpus callosum (genu) | 14 | 29 | 2 | 3.69 | 122 |
| R corpus callosum (body-middle) | 14 | −11 | 36 | 3.21 | 74 |
| svPPA centre-embedded | |||||
| L inferior longitudinal | −36 | −59 | 4 | 4.00 | 127 |
| emsp;bvFTD long | |||||
| L corpus callosum (body-middle)/corona radiata | −18 | −8 | 42 | 3.28 | 68 |
| R corpus callosum (body-posterior)/cingulum | 14 | −20 | 30 | 3.59 | 128 |
| B corpus callosum (body-middle) | 0 | 1 | 28 | 3.43 | 154 |
| bvFTD centre-embedded | |||||
| L inferior frontal-occipital | −35 | −12 | −6 | 3.24 | 65 |
| L corpus callosum (body-middle)/corona radiata | −18 | −8 | 42 | 3.12 | 57 |
| R corpus callosum (body-posterior)/corona radiata | 14 | −20 | 30 | 3.17 | 68 |
| R corpus callosum (genu)/corona radiata | 20 | 32 | 6 | 3.11 | 67 |
*
indicates a cluster peak for a regression relating performance to atrophy at a level approaching significance (p<0.002) in a hypothesised area. bvFTD, behavioural-variant frontotemporal degeneration; lvPPA, logopenic variant primary progressive aphasia; naPPA, MNI; Montreal Neurological Institute, non-fluent/agrammatic primary progressive aphasia; svPPA, semantic variant primary progressive aphasia