Figure 2. Differential trans interactions. (A) Ideograms of chromosomes with regions interacting with COMT in all 4 normal B lymphocyte cell lines and ≤ 1 22q11DS B lymphocyte cell lines are depicted by orange bars. Heat map represents known gene density. Region defined as 20 consecutive overlapping windows of 100 restriction sites, sliding by 1 site. (B) Magnified view of 1 selected differentially interacting region on chromosome 4. Significant COMT interacting windows (gray bars) are present in all normal and none of the 22q11DS B lymphocyte cell lines. The transcription start site of SORCS2 a bipolar disorder, and schizophrenia associated gene (red) is highlighted. Image generated from UCSC genome browser GRCh37/hg19 and Ideographica software.