Figure 2. Biodefense enterprise system for global pathogen awareness and countermeasure deployment. This global awareness system will integrate information collected by software agents and artificial intelligence algorithms capable of prioritizing and classifying pathogen genomic information and its associated metadata to yield specifics of potential actors, their capabilities, and potential feasibilities. This effort consists in the integration, annotation, disambiguation, evaluation, and representation of genomic and open source metadata information to conduct assessment including available and projected capability. This differs from other biosurveillance techniques that are assembled (and evaluated) for the purpose of pathogen detection and prediction without considering technology and future trends of technological capabilities. The system includes the most likely and most stressing threats and identify intelligence gaps (if any) that can affect the efficacy of any countermeasure program.