Table 1. Patient characteristics.
Age in years/Sex | No. of Prior Inductions | Pretreatment Karyotype | Presenting WBC count × 103/uL | % BM blasts | Response |
---|---|---|---|---|---|
45/M | 2 | 46,XY,t(6;11)(q27;q23)/46,XY | 2.7 | 4 | PD |
71/M | 4 | 46, XY | 12.3 | 84 | PD |
66/M | 3 | 46,XY,t(9;17;10)(q34;p12;q22)/46,XY | 1.3 | 81 | CR |
70/M | 3 | 94<4n>,XXYY,+13,+13/46,XY | 1.6 | 8 | CRi** |
75/F | 1* | 73-87<4n>, XXXX,-7,-7,t(8;21)(q22;q22)x2,-11,-14,-16, -20 | 3.6 | 93 | CRi** |
50/M | 3 | 48,XX,t(6;11)(q27;q23),+21,+21/46,XX | 17.2 | 90 | PD |
58/F | 2* | 46,XX,t(6;9)(p23;q24)/47,sl,+i(13)(q10)/ 47,sl,+mar | 19.1 | 87 | PD |
51/M | 3 | 47,XY+8/46,XY | 0.5 | 11 | PD |
65/M | 1 | 46,XY,t(4;12)(q12;p13)/46,XY | 4.1 | 2 | CR** |
72/M | 1* | 46,XY,t(4;21)(q33;q22)/46,idem,der(3)t(3;4)(p22;q12) -4, add(8)(p12),+mar /48,XY,+21,+21 | 1.0 | 42 | PR |
49/F | 2 | 46,XX,t(6;11)(q27;q23)/46,XX | 6.3 | 85 | PD |
68/F | 2* | 43,XX,add(1)(q32),add(5)(q13),-6,-7, der(8) t(8;21)(p21;q11.2), add(12)(p11.2)13, dic(18;22)(q12;p12),der(19)t(6;19)(q11.2;p13.3) ins(19;?)(p13.3;?),der(19)t(13;19)(q14;q13.3), +20,del(20)(q11.2)x2, -21,+mar1[cp2]/46,XX | 2.3 | 15-20 | PD |
76/M | 1* | 44,X,-Y,add(5)(q12),-7,del(8)(q?24),dic(?;12)(?;p11.2), der(16)t(16;17)(p13. 3;q12),-17,add(17)(p11.2),-18,-20, der(21) t(Y;21)(q11.23;p11.2),22,+r,+mar10, +mar11,+mar12/ 44,idem,del(3)(p11.2p21) +mar9, -mar12/46,XY | 4.3 | 72 | PD |
62/F | 1* | 46, XX | 2.5 | 35 | PD |
65/M | 2 | 46,XY,del(11)(q13q23)/46,XY | 39.1 | 8 | PD |
65M | 1 | 46,XY,t(14;16)(q24;p13.3)/46,XY | 24.5 | 10 | PD |
60/M | 4 | 46,XY,t(9;22)(q34;q11.2)/46,XY,idem,del(6)(p23) | 12.6 | 14 | PD |
75/M | 5* | 46,XY,dup(1)(q21q41)/46,XY | 59.1 | 82 | PD |
50/M | 3 | 46,XY | 2.3 | 5-7 | PD |
77/F | 2* | 46,XX,del(5)(q22q35)/46,XX | 1.8 | 26 | PD |
42/F | 5 | 46,XX | 3.7 | 23 | CRi |
81/F | 1* | 46,XX | 3.1 | 3 | PD |
77/M | 1* | 46,XY | 7.9 | 47 | PD |
PD (Progressive disease)
Prior decitabine treatment
Patient achieved cytogenetic remission