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Synthesis of pyrrolidines 7 and 23. (a) TBAF, THF, 0 °C to rt, 97%; (b) methacrylic anhydride, Et3N, DMAP, CH2Cl2rt, 82%; (c) (i) TFA/H2O, (95:5) (ii) PS-BH(OAc)3, DCE, rt, (iii) allyl iodide, K2CO3, DMF, rt, 47% over 3 steps. DMAP = 4-Dimethylaminopyridine; PS = polymer supported.
