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. Author manuscript; available in PMC: 2014 May 21.
Published in final edited form as: Nature. 2013 Sep 22;503(7476):360–364. doi: 10.1038/nature12632

Figure 5. miR-430 activity is abrogated by Nanog LOF.

Figure 5

a. In situ showing degradation of miR-430 target cd82b at 6hpf in wild type, compared to stabilization in MZdicer (lacking miR-430 activity). b. cd82b is stabilized in the Nanog-SoxB1 LOF embryo, indicating loss of miR-430 activity. The effect is rescued with injection of nanog and soxB1 mRNA. c. Cumulative plots showing stabilized expression of miR-430 targets in MZdicer and LOF embryos, compared to wild type. P values are for two-sided Wilcoxon rank sum tests comparing each miR-430 target group to non-targets.