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. 2011 Apr;1813(4):623–633. doi: 10.1016/j.bbamcr.2010.08.007

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© 2011 Elsevier B.V.

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Fig. 2 — PINK1 and parkin in mitophagy—proposed model. Upon mitochondrial membrane depolarisation, full-length PINK1 accumulates at the outer mitochondrial membrane and NIX translocates to the mitochondria. NIX and full-length PINK1 recruit parkin to the mitochondria, which leads to parkin-dependent ubiquitination of VDAC. Ubiquitination of VDAC recruits p62 while NIX recruits GABARAP to the mitochondria. NIX binds LC3, which additionally binds p62 and depolarised mitochondria are removed via autophagy.