Table 1.
Patient characteristics according to hematological toxicity in 399 consecutive patients with metastatic colorectal cancer n (%)
| All (n = 399) |
Anemia (n
= 397) |
Neutropenia (n
= 396) |
Thrombopenia (n
= 396) |
||||||||||||||
| No (n = 33) | Yes (n = 364) | P | No (n = 114) | Yes (n = 282) | P | No (n = 163) | Yes (n = 233) | P | |||||||||
| Mean ± SD | 65 ± 11 | 66.5 ± 10 | 64.9 ± 11.1 | 0.508 | 69 ± 11.7 | 63.5 ± 10.4 | < 10-4 | 67.4 ± 11.2 | 63.4 ± 10.7 | < 10-3 | |||||||
| Median (min-max) | 65.5 (24.7-90.7) | 67.8 (50-85.8) | 65.5 (24.7-90.7) | 69.6 (44.4-90.7) | 63.5 (24.7-85.8) | 67.5 (24.7-90.7) | 63.5 (28.2-88.2) | ||||||||||
| Origin | 0.994 | 0.622 | 0.392 | ||||||||||||||
| Colon | 314 | (79.1) | 26 | (78.8) | 287 | (78.8) | 88 | (77.2) | 224 | (79.4) | 125 | (76.7) | 187 | (80.3) | |||
| Rectum | 85 | (21.4) | 7 | (21.2) | 77 | (21.2) | 26 | (22.8) | 58 | (20.6) | 38 | (23.3) | 46 | (19.7) | |||
| Gender | 0.554 | 0.106 | 0.559 | ||||||||||||||
| Male | 213 | (53.4) | 16 | (48.5) | 196 | (53.8) | 68 | (59.6) | 143 | (50.7) | 84 | (51.5) | 127 | (54.5) | |||
| Female | 186 | (46.6) | 17 | (51.5) | 168 | (46.2) | 46 | (40.4) | 139 | (49.3) | 79 | (48.5) | 106 | (45.5) | |||
| WHO PS | 0.233 | 0.024 | 0.139 | ||||||||||||||
| 0 | 134 | (47.9) | 16 | (72.7) | 117 | (45.5) | 26 | (32.1) | 107 | (54.0) | 49 | (40.2) | 84 | (53.5) | |||
| 1 | 102 | (36.4) | 5 | (22.7) | 97 | (37.7) | 34 | (42.0) | 68 | (34.3) | 52 | (42.6) | 50 | (31.8) | |||
| 2 | 33 | (11.8) | 1 | (4.5) | 32 | (12.5) | 16 | (19.8) | 17 | (8.6) | 14 | (11.5) | 19 | (12.1) | |||
| 3 | 8 | (2.9) | 0 | (0) | 8 | (3.1) | 3 | (3.7) | 5 | (2.5) | 5 | (4.1) | 3 | (1.9) | |||
| 4 | 3 | (1.1) | 0 | (0) | 3 | (1.2) | 2 | (2.5) | 1 | (0.5) | 2 | (1.6) | 1 | (0.6) | |||
| Missing | 119 | 11 | 107 | 33 | 84 | 41 | 76 | ||||||||||
| Metastatic sites | 0.264 | 0.646 | 0.774 | ||||||||||||||
| Single | 241 | (60.6) | 23 | (69.7) | 217 | (59.8) | 71 | (62.3) | 168 | (59.8) | 100 | (61.3) | 139 | (59.9) | |||
| Multiple | 157 | (39.4) | 10 | (30.3) | 146 | (40.2) | 43 | (37.7) | 113 | (40.2) | 63 | (38.7) | 93 | (40.1) | |||
| Missing | 1 | 0 | 1 | 0 | 1 | 0 | 1 | ||||||||||
| Leucocyte count | 0.151 | 0.337 | 0.501 | ||||||||||||||
| < 10000 | 219 | (74.2) | 20 | (87.0) | 198 | (73.3) | 60 | (70.6) | 158 | (76.0) | 89 | (72.4) | 129 | (75.9) | |||
| ≥ 10000 | 76 | (25.8) | 3 | (13.0) | 72 | (26.7) | 25 | (29.4) | 50 | (24.0) | 34 | (27.6) | 41 | (24.1) | |||
| Missing | 104 | 10 | 94 | 29 | 74 | 40 | 63 | ||||||||||
| ALP | 0.138 | 0.023 | 0.344 | ||||||||||||||
| < 300 | 217 | (81.0) | 19 | (95.0) | 197 | (79.8) | 53 | (71.6) | 163 | (84.5) | 85 | (78.0) | 131 | (82.9) | |||
| ≥ 300 | 51 | (19.0) | 1 | (5.0) | 50 | (20.2) | 21 | (28.4) | 30 | (15.5) | 24 | (22.0) | 27 | (17.1) | |||
| Missing | 131 | 13 | 117 | 40 | 89 | 54 | 75 | ||||||||||
| Prior anemia | < 10-4 | 0.103 | 0.763 | ||||||||||||||
| Grade 0 | 175 | (44.8) | 28 | (84.8) | 145 | (40.7) | 41 | (38.0) | 132 | (47.1) | 69 | (42.3) | 104 | (45.2) | |||
| Grade 1-2-3-4 | 216 | (55.2) | 5 | ( 15.2) | 211 | (59.3) | 67 | (62.0) | 148 | (52.9) | 89 | (54.6) | 126 | (54.8) | |||
| Missing | 8 | 0 | 8 | 6 | 2 | 5 | 3 | ||||||||||
| CEA | |||||||||||||||||
| n | 307 | 23 | 282 | 90 | 215 | 126 | 179 | ||||||||||
| Mean ± SD | 455.3 ± 1979.3 | 43.7 ± 116.3 | 491.1 ± 2061.4 | 0.008 | 714.8 ± 2643 | 349.6 ± -1629.8 | 0.389 | 487.6 ± 1736.2 | 436.1 ± 2148.4 | 0.219 | |||||||
| Median (min-max) | 18 (0.1-20820) | 5.7 (0.3-508.9) | 19.4 (0.1-20820) | 19.2 (0.1-18380) | 15.6 (0.2-20820) | 21.1 (0.4-14660) | 15.4 (0.1-20820) | ||||||||||
| LDH | |||||||||||||||||
| n | 261 | 20 | 240 | 73 | 187 | 103 | 157 | ||||||||||
| Mean ± SD | 496.4 ± 860.1 | 299.6 ± 225.4 | 513.3 ± 892.8 | 0.282 | 506.7 ± 837.6 | 493 ± 873.1 | 0.374 | 530.8 ± 982.5 | 474.5 ± 774.8 | 0.244 | |||||||
| Median (min-max) | 233 (82-7230) | 224 (117-878) | 234 (82-7230) | 249 (113-6190) | 227 (82-7230) | 248 (83-7230) | 227 (82-6450) | ||||||||||
| Vital status | 0.04 | 0.015 | 0.842 | ||||||||||||||
| Death | 311 | (77.9) | 21 | (63.6) | 288 | (79.1) | 98 | (86.0) | 211 | (74.8) | 128 | (78.5) | 181 | (77.7) | |||
| Censored | 88 | (22.1) | 12 | (36.4) | 76 | (20.9) | 16 | (14.0) | 71 | (25.2) | 35 | (21.5) | 52 | (22.3) | |||
WHO PS: WHO performance status; ALP: Alkaline phosphatase; CEA: Carcinoembryonic antigen; LDH: Lactate dehydrogenase.