Immunolocalization of cyclooxygenase 2 in gastric tissue. A, B: The results in the control group; C, D: A scarce cyclooxygenase 2 (COX-2) immunoreactivity in sub-glandular region of hydrogen plus aspirin-treated rats; E, F: An apparent COX-2 immunoreactivity in the glandular region and epithelial necks of stomach tissues of rats treated with aspirin (A, C, E: × 200 and B, D, F: × 400).