Table 5.
Multivariate analysis of factors associated with OS and DFS
| Characteristics | OS | DFS | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | |
| Periostin (negative vs. positive) | 2.393 | 1.065-5.377 | 0.035 | 2.395 | 1.066-5.381 | 0.034 |
| Age (≤60 vs. >60) | 1.184 | 0.654-2.143 | 0.577 | 0.864 | 0.458-1.632 | 0.653 |
| Gender (male vs. female) | 0.853 | 0.452-1.610 | 0.624 | 1.155 | 0.638-2.091 | 0.634 |
| Tumor size, cm (≤5 vs. >5) | 1.567 | 0.846-2.902 | 0.153 | 1.519 | 0.818-2.818 | 0.185 |
| Lymphatic metastasis (no vs. yes) | 1.658 | 0.915-3.004 | 0.096 | 1.665 | 0.918-3.018 | 0.093 |
| Tumor differentiation (high, moderate vs. low) | 0.392 | 0.211-0.726 | 0.003 | 0.363 | 0.196-0.673 | 0.001 |
| Venous invasion (no vs. yes) | 2.292 | 1.262-4.162 | 0.006 | 2.313 | 1.275-4.194 | 0.006 |
| Tumor location (upper vs. middle, low) | 0.899 | 0.470-1.722 | 0.749 | 0.918 | 0.491-1.718 | 0.789 |
| TNM (no vs. yes) | 2.934 | 1.635-5.266 | 0.000 | 3.047 | 1.714-5.417 | 0.000 |