Table 3.
The genotype and allele frequencies of SNPs in and around the CHL1 gene in AIS in a Chinese Han population
| Genotype | AIS (%) | Control (%) | P-value (χ2) | Alleles | AIS (%) | Control (%) | P-value (χ2) | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|
| rs2272524 |
|
|
|
|
|
|
|
|
| CC |
56(30.1) |
43(25.4) |
|
C |
202(54.3) |
169(50.0) |
|
C vs. T |
| CT |
90(48.4) |
83(49.1) |
0.53 |
T |
170(45.7) |
169(50.0) |
0.25 |
1.12 (0.89-1.60) |
| TT |
40(21.5) |
43(25.4) |
|
|
|
|
|
|
| rs331894 |
|
|
|
|
|
|
|
|
| GG |
48(25.8) |
39(23.1) |
|
G |
186(50.0) |
170(50.3) |
|
G vs. A |
| GA |
90(48.4) |
92(54.4) |
0.52 |
A |
186(50.0) |
168(49.7) |
0.94 |
0.99 (0.74-1.33) |
| AA |
48(25.8) |
38(22.5) |
|
|
|
|
|
|
| rs2272522 |
|
|
|
|
|
|
|
|
| CC |
78(41.9) |
82(48.5) |
|
C |
236(63.4) |
240(71.0) |
|
C vs. T |
| CT |
80(43.0) |
76(45.0) |
0.03 |
T |
136(36.6) |
98(29.0) |
0.03 |
0.71 (0.52-0.97) |
| TT |
28(15.1) |
11(6.5) |
|
|
|
|
|
|
| rs2055314 |
|
|
|
|
|
|
|
|
| CC |
59(31.7) |
34(20.1) |
|
C |
199(53.5) |
150(44.4) |
|
C vs. T |
| CT |
81(43.5) |
82(48.5) |
0.04 |
T |
173(46.5) |
188(55.6) |
0.02 |
1.44 (1.07-1.94) |
| TT |
46(24.7) |
53(31.4) |
|
|
|
|
|
|
| rs10510181 |
|
|
|
|
|
|
|
|
| GG |
57(30.6) |
36(21.3) |
|
G |
199(53.5) |
152(45.0) |
|
G vs. A |
| GA |
85(45.7) |
80(47.3) |
0.08 |
A |
173(46.5) |
186(55.0) |
0.02 |
1.41 (1.05-1.89) |
| AA | 44(23.7) | 53(31.4) |
SNP: single nucleotide polymorphism; AIS: adolescent idiopathic scoliosis.
OR: odds ratio, CI: confidence interval.