Fig. 1.

Neutralization of EV71 by monoclonal antibodies E18 and E19. Whole IgG and Fab fragments of the monoclonal antibodies E18 (A) and E19 (B) were used to inhibit EV71 at different concentrations (x axis) by using a plaque reduction neutralization test. The red symbols represent whole antibody and the blue symbols represent Fab fragments. Inhibition of virus was represented as the percentage of plaques relative to plaques in the control wells. We demonstrated neutralization of EV71 by Fab fragments as well as by whole IgG, with whole IgG being more efficient than Fab fragments.