Table 1.

Treatment with XIB4035 preserves Remak bundle structure in line-D mice

	C-fiber area†	C-fibers/Remak bundle‡
WT +vehicle	1.78 ± 0.10 mm2	9.90 ± 0.66
WT +XIB4035	1.81 ± 0.06 mm2	8.80 ± 0.52
Line-D +vehicle	1.01 ± 0.07 mm2*	4.71 ± 0.42*
Line-D +XIB4035	1.64 ± 0.07 mm2	8.40 ± 0.83

Animals were treated with XIB4035 or vehicle from P21 to P49. Sciatic nerves were prepared for EM, and the cross-sectional area of individual unmyelinated axons and the number of axons pre-Remak bundles were quantified.

^*P < 0.001; ANOVA Newman–Keuls post hoc.

^†n = 3 animals per genotype; ≥50 axons per animal.

^‡n = 3 animals per genotype; ≥16 bundles per animal.