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. 2014 Jan 27;111(6):2152–2157. doi: 10.1073/pnas.1314226111

Fig. 5.

Fig. 5.

FANCC and CtBP1 act as transcriptional repressors of DKK1. (A–E) Luciferase assays performed in HeLa cells transfected with the DKK1 promoter reporter construct along with equimolar amounts of β-catenin and TCF4 expression vectors and with control empty vectors or various concentrations of FANCC (A), CtBP1 (B), FANCC with CtBP1 (C), FANCCL554P (D), or FANCCL554P with CtBP1 (E) as indicated. (F) Luciferase assays performed in patient-derived FANCC-deficient (PD331) and FANCC-corrected (PD331/C) cells transfected with the DKK1 promoter reporter construct and treated with CT99021 or LiCl. The number of experiments performed in duplicate is indicated in each graph. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.