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Stimulation of the mPR with progesterone increases JNK1/2 and p38 MAPK activity. Immunoblot analysis of SKOV-3 cells stimulated with progesterone (100 or 1,000 nM) demonstrated a time- and dose-dependent increase in phosphorylation of both JNK isoforms (p-JNK1 and p-JNK2) as well as p38 (p-p38). Total JNK1/2 (t-JNK1 and t-JNK2) and total p38 (t-p38) expression was unchanged with progesterone treatment
