Fig. 1.

Oxidative damage in foetal guinea pig brains. Markers of increased oxidation and suggestive oxidative damage in the brain of guinea pigs subjected to prenatal vitC deficiency (DEF) (dark bars) or control diet (CTRL) (light bars) during development. Foetuses were excised by caesarean section at GD 45 and GD 56. (A) Densitometric analysis of HNE modified proteins in brain homogenate; results are normalized to actin; (B) Malondialdehyde in brain homogenate, measured by HPLC; (C). Densitometric analysis of nitrotyrosine modified proteins normalized to actin. Data are expressed as means±SD. ^⁎p<0.05; ^⁎⁎⁎p<0.0001 by ANOVA.