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. Author manuscript; available in PMC: 2015 Jan 3.
Published in final edited form as: Org Lett. 2013 Nov 27;16(1):220–223. doi: 10.1021/ol403209k

Scheme 2.

Scheme 2

Amination of Aryl Chlorides using LiOtBua

aReaction conditions: aryl chloride (1.0 mmol), amine (1.5 mmol), LiOtBu (1.5 mmol), 2 (5 mol %), dppf (5 mol %), MeCN (1.0 mmol), CPME (2 mL), 100 °C, 1 h. Yields are of the isolated product, average of two runs. bReaction time 16 h. c2 (10 mol %) and dppf (10 mol %), 130 °C, 16 h.