Scheme 2.
Amination of Aryl Chlorides using LiOtBua
aReaction conditions: aryl chloride (1.0 mmol), amine (1.5 mmol), LiOtBu (1.5 mmol), 2 (5 mol %), dppf (5 mol %), MeCN (1.0 mmol), CPME (2 mL), 100 °C, 1 h. Yields are of the isolated product, average of two runs. bReaction time 16 h. c2 (10 mol %) and dppf (10 mol %), 130 °C, 16 h.