Table 1.
Clinical Characteristics According to Prognosis
| Good prognosisa(n=78) | Poor prognosisb(n=74) | p | |
|---|---|---|---|
| Mean age at diagnosis (years) | 39.1±17.3 | 52.3±13.0 | <0.001 |
| Male:female (male %) | 13:65 (16.7) | 20:54 (27.0) | 0.121 |
| Pathology of primary tumor | |||
| Size (cm) | 2.4±1.7 | 3.3±2.0 | 0.015 |
| PTC:FTC (FTC %) | 70:8 (10.3) | 55:19 (25.7) | 0.012 |
| Multiplicity, present % | 40.0 | 48.6 | 0.443 |
| Extrathyroidal invasion, gross, present % | 27.8 | 30.8 | 0.783 |
| LN metastasis, present % | 42.6 | 58.5 | 0.123 |
| Timing of metastasisc | <0.001 | ||
| Pre-op, n (%) | 3 (27.3) | 8 (72.7) | |
| Immediate, n (%) | 53 (67.1) | 26 (32.9) | |
| Late, n (%) | 22 (35.5) | 40 (64.5) | |
| Sites of metastasis | |||
| Lung only:multiple (multiple %) | 73:3 (3.9) | 52:18 (25.7) | <0.001 |
| Pattern of lung uptake in WBS | <0.001 | ||
| Bilateral diffuse, n (%) | 35 (89.7) | 4 (10.3) | |
| Focal, n (%) | 27 (57.4) | 20 (42.6) | |
| Nonavid, n (%) | 6 (15.0) | 34 (85.0) | |
| Size of lung lesions from radiologic examd | |||
| Micro:macro (macro %) | 13:12 (48.0) | 8:50 (86.2) | <0.001 |
a
Good prognosis: no evidence of disease or stable disease.
b
Poor prognosis: progression of disease or death.
c
Pre-op: lung metastasis diagnosed during initial preoperative work-up; immediate: metastasis diagnosed by WBS during initial 131I remnant ablation; late: diagnosed by WBS or radiologic examination performed due to the increases of T4-suppressed Tg or stimulated (off T4) Tg after initial evaluation or 131I remnant ablation.
d
Micro: micronodule, where the largest size of the nodule is <1 cm; macro: macronodule, where the largest size of the nodule is ≥1 cm.
FTC, follicular thyroid carcinoma; LN, lymph node; PTC, papillary thyroid carcinoma; T4, thyroxine; WBS, whole-body scan.