Table 2.
Total and Stratified Analysis of ABCC2 G1249A Polymorphism on the Risk of Drug Resistance in Epilepsy
| AA vs. GG | GA vs. GG | A vs. G | Recessive model | Dominant model | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variables | OR (95% CI) | pa | I2 (%) | OR (95% CI) | pa | I2 (%) | OR (95% CI) | pa | I2 (%) | OR (95% CI) | pa | I2 (%) | OR (95% CI) | pa | I2 (%) |
| Total | 0.372 (0.182–0.762) | 0.916 | 0.0 | 0.977 (0.704–1.355)b | 0.046 | 55.7 | 0.914 (0.761–1.098) | 0.104 | 45.3 | 0.399 (0.200–0.795) | 0.827 | 0.0 | 0.976 (0.795–1.199) | 0.056 | 53.6 |
| Ethnicity | |||||||||||||||
| Asian | 0.357 (0.123–1.041) | 0.731 | 0.0 | 1.133 (0.893–1.437) | 0.310 | 16.2 | 1.010 (0.814–1.252) | 0.239 | 28.9 | 0.356 (0.123–1.035) | 0.726 | 0.0 | 1.075 (0.852–1.358) | 0.260 | 25.3 |
| Caucasian | 0.388 (0.148–1.013) | 0.666 | 0.0 | 0.646 (0.212–1.966)b | 0.021 | 81.1 | 0.700 (0.494–0.992) | 0.206 | 37.5 | 0.441 (0.178–1.092) | 0.368 | 0.0 | 0.699 (0.453–1.078) | 0.052 | 73.5 |
The results that are in bold type show statistical significance.
a
p-Value of Q-test for heterogeneity test.
b
Random-effects model was used when p-value for heterogeneity test<0.05; otherwise, fixed-effects model was used.
CI, confidence interval; OR, odds ratio.