FIG. 2.

MSC migration to the defect side on the right femur in the six groups. On the left side in the upper row, mice are shown 5 min postinjection indicating systemic cell distribution of reporter cells. In the lower row, mice are shown at day 8. Red rectangles indicate the regions of interest over the right and the left femur diaphysis. The graph on the right side shows the ratio of the luminescent signal on the right (OP) versus the left femur (non-OP) (quantitative analysis). A comparison of all groups showed statistically significant differences (p<0.0001, one-way ANOVA). Post hoc testing showed significant intergroup differences between the following treatment groups and the negative control group (p<0.05, Tukey test): [BMP-2, SDF-1α, CXCR4(+) MSCs]; [BMP-2, CXCR4(+) MSCs]; [SDF-1α, CXCR4(+) MSCs]. MSC, mesenchymal stromal cell. Color images available online at www.liebertpub.com/tea