FIG. 3.
Data for thyrocytes of mice sacrificed at 5–12+ months of age. (A) y-axis indicates the percentage of cells in the given genotypes that have the number of signals shown on the x-axis. (B) y-Axis indicates the number of signals per 100 thyrocytes observed at an intensity shown on the x-axis. In nuclei of ThrbPV/PV thyrocytes, a higher numbers of less intense telomere signals were observed, whereas in nuclei of the ThrbPV/+ thyrocytes higher intensity signals were detected than in the nuclei of age-matched controls. (C) Representative H&E stained thyroid tissue sections and individual thyrocyte nuclei taken from each genotype, DAPI nuclear stain with rhodamine-labeled telomere signals, (i) homozygous normal Thrb+/+, (ii) heterozygous ThrbPV/+ mutant, (iii) homozygous ThrbPV/PV mutant, shown as both 2D and 3D side nuclear images of telomere signals. (D) Data from representative mouse thyroid samples of each genotype showing signal intensity versus number of signals. (E) Data from representative mouse thyroid samples of each genotype showing the number of signals per thyrocyte. Arrows highlight multiple ThrbPV/PV thyrocyte populations with specific signal counts.