Table 1.
Illustrative Homologies Between NY-ESO-1, the Thyrotropin Receptor, and HLA Antigens
| NY-ESO-1 vs. TSH-R | A2 | A11 | A26 (10) | A30 (19) | A33 (19) | DPw2 | DPw4 | DQ2 | DQ6 (1) | DQ7 (3) | DQ8 (3) | DR4 | DR9 | DR15 (2) | DR53 | DR51 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NY-ESO-1 82–102 TSH-R 227–245 |
2 1 |
3 6 |
1 1 |
1 1 |
||||||||||||
| NY-ESO-1 94–116 TSH-R 300–322 |
1 1 |
1 2 |
1 1 |
|||||||||||||
| NY-ESO-1 139–161 TSH-R 75–98 |
1 1 |
2 2 |
1 1 |
3 2 |
||||||||||||
| NY-ESO-1 146–163 TSH-R 506–524 |
1 1 |
1 1 |
1 2 |
1 1 |
4 4 |
1 1 |
||||||||||
| NY-ESO-1 156–179 TSH-R 661–687 |
1 3 |
1 1 |
1 1 |
1 2 |
4 2 |
1 2 |
3 4 |
1 2 |
1 1 |
The patient's HLA antigens are highlighted in gray.
TSH-R, thyrotropin receptor.