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. Author manuscript; available in PMC: 2014 Feb 17.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Dec 7;22(2):1023–1026. doi: 10.1016/j.bmcl.2011.11.128

Scheme 1.

Scheme 1

(a) NaHCO3, H2O2, THF, 58%; (b) MOMCl, NaI, DIPEA, DMA, 80 °C, 60%; (c) EtOMeCl, NaI, DIPEA, DMA, 80 °C, 65%; (d) NBS (1.1 equiv), CHCl3, 28%; (e) NBS (2.2 equiv), CHCl3, 31%.