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. Author manuscript; available in PMC: 2014 Feb 17.
Published in final edited form as: Biotechnol Bioeng. 2010 Jan 1;105(1):121–129. doi: 10.1002/bit.22525

Figure 2.

Figure 2

Initial rate of aggregation as a function of steel surface area. The mAb was at 1.0 mg/mL. Data is presented as a log10-log10 plot. Data is the average aggregation rate and the error bars represent the 95% confidence interval of the aggregation rates. Rate data from: soluble aggregates appearance (●); decrease in monomer levels (○). The line represents the regression fit to the increase in soluble aggregates data with the slope fixed at 2.0 ± 0.3 (r2 = 0.88), with intercept of −4.6 ± 0.9 (quoted errors are standard errors of the fit). Allowing the slope to float results in a slope of 2.1 ± 0.3 (r2 = 0.88) and so is not significantly different than a slope of 2.0. The fit to the monomer loss data gives a slope of 1.7 ± 0.6, and intercept of −4 ± 2with r2 = 0.6.