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. 2014 Jan 29;2014:698617. doi: 10.1155/2014/698617

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Copyright © 2014 Wen-Chin Yang.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

The underlying mechanism of the crude extract of B. pilosa (BP) and its active compound, compound 19 (CP), in T1D. BP and/or CP can suppress T1D development via regulation of T cells (① and ②) and β cells (③) in NOD mice (a). Their regulation of T cells involves Th cell activation and differentiation (①) and partial depletion of Th0 cells (②) as depicted (b). CP and/or BP augment the expression of GATA-3 gene and, in turn, promote the expression of IL-4 and Th2 cell differentiation. In contrast, CP and/or BP do not affect the expression of T-bet (c).