Elastin-like protein hydrogels can be formed in any shape, including that of a conduit. (A) A hollow tube was molded from 10 wt% ELP (1:1 crosslinking ratio) stained with blue food coloring to aid visualization (length ~20 mm, outer diameter ~5 mm, inner diameter ~3 mm). (B) This hollow conduit was filled with a second ELP solution (3 wt%, 1:1 crosslinking ratio, stained red) that is suitable for neurite extension. The conduit can freely support itself (lower right), but is flexible and compliant.