Table 1.

KRAS and TP53 Mutations.

		KRAS					TP53
		chr12:25398284C>A	chr12:25398284C>T	chr12:25398285C>G	chr12:25398285C>A	chr12:25380275T>G	chr17:7574020TC>T	chr17:7577022G>A	chr17:7577094G>C	chr17:7577559G>A	chr17:7578406C>T	chr17:7579406G>T
	G12 Read Depth	Alternative Allele Reads
		G12V	G12D	G12R	G12C	Q61H	E204fs	R174*	R150P	S109F	R136H	S55*
2P3	33		9			43,0	13,0	66,0	37,0	80,0	3,14	32,0
2T	28		11			39,0	27,0	81,0	55,0	86,0	14,7	29,0
3P3	38	3				36,0	23,0	84,0	52,0	85,0	23,0	36,0
3T	29	4				30,0	16,0	60,0	35,0	80,0	25,0	26,0
4P2	38					57,0	16,0	71,0	41,0	78,0	7,14	26,0
4T	11					29,0	19,0	76,0	46,0	88,0	9,7	35,0
6P2-2	43	3				40,13	24,0	78,0	60,0	87,0	25,0	34,0
6P2-1	38	3				45,1	16,0	71,0	46,0	81,0	24,0	30,0
6T	29	7				51,0	18,0	72,0	51,0	23,50	14,0	31,0
8P2	54			14		82,0	33,0	65,0	9,20	42,0	28,0	98,0
8P3	54			8		52,0	24,0	62,0	19,17	31,0	30,0	102,0
8T	34			4		61,0	35,0	88,0	34,13	43,0	43,0	137,0
10P2	18		3			38,0	19,0	56,0	26,0	23,0	16,0	56,0
10T	13					19,0	20,0	48,0	21,0	21,0	12,0	59,0
12P2	40	4	5			42,0	21,0	56,0	28,0	3,0	25,0	79,1
12P3	55		19			54,0	10,0	26,0	12,0	5,0	8,0	47,0
12T	52		8			57,0	17,0	64,0	49,0	30,0	31,0	77,17
30P3	18	2				22,0	13,0	38,0	24,0	20,0	20,0	30,0
30T	17		3			29,0	5,6	22,0	7,0	24,0	16,0	30,0
37P2	40		12		7	42,0	19,0	80,0	36,0	34,0	27,0	80,0
37P3	39				15	40,0	10,0	62,0	24,0	28,0	23,0	88,0
37T	8	5				20,0	4,0	22,32	30,0	11,0	8,0	23,0
41P2	27	9			1	46,0	27,0	88,0	52,0	39,1	42,1	120,1
41P3	27	10				56,0	24,0	60,0	35,0	31,0	13,0	81,0
41T	28	3				48,0	46,0	122,0	50,0	55,0	62,0	136,0

Positions listed as Chrom:positionRef>Alt Comma separated numbers: Reference Allele, Alternative Allele Reads T: tumor; P2: PanIN2; P3: PanIN3; Indel: insertion or deletion