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. 2013 Dec 23;33(3):499–506. doi: 10.3892/ijmm.2013.1603

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Copyright © 2014, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Treatment with PP1–12 attenuates ischemia/reperfusion (I/R) injury-induced myocardial apoptosis. TUNEL assay (x400 magnification) on (A) sham-operated, (B) I/R (vehicle-treated,. DMSO), (C) I/R + S1 (1 mg/kg/day), (D) I/R + S3 (3 mg/kg/day) and (E) I/R + S10 (10 mg/kg/day) groups. (F) Mean percentage of apoptotic cells (apoptotic index) for the same groups. I/R + S1, S3 and S10, I/R treated with 1, 3 and 10 mg/kg/day PP1–12, respectively. Results are shown as the means ± SD. ^*P<0.05 vs. the sham-operated group; ^#P<0.05 vs. the I/R (vehicle-treated, DMSO) group. Black arrows indicate the TUNEL-positive cells.