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. 1978 Jun;75(6):2805–2809. doi: 10.1073/pnas.75.6.2805

Steroid hormones mediate reversible phenotypic transition between transformed and untransformed states in mouse fibroblasts.

M C Armelin, H A Armelin
PMCID: PMC392653  PMID: 275850

Abstract

Hydrocortisone at physiological concentrations reversibly inhibits DNA synthesis in ST1 cells (a line of mouse fibroblasts possessing 40 chromosomes and derived from Swiss 3T3 cells). This inhibitory activity is a property of glucocorticoids, but the beta-OH of C-11 of glucocorticoids is not essential for the inhibition. The steroid hormone restores to ST1 cells dependency on serum, density, and anchorage for growth. When injected into nude mice, ST1 cells generated malignant invasive fibrosarcoma. Injections of dexamethasone into tumor-bearing animals blocked tumor growth. The steroid hormone seems to induce a reversible transition between a transformed and a "normal" phenotype. ST1 cells treated or untreated with hydrocotisone are not responsive to fibroblast growth factor, epidermal growth factor, or prostaglandin F2alpha whereas they are responsive to a factor that is a contaminant in bovine serum albumin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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